![]() ![]() ![]() Indeed, one of our patients developed severe immune-related myocarditis, resulting in acute pulmonary edema and cardiogenic shock, with a left ventricular ejection fraction reduction to 25%, requiring several days of noninvasive ventilation and inotropic support. 3 Therefore, the benefits of immune checkpoint inhibition (ICI) may be overshadowed. Although these treatments are essential for the management of irAEs, they are also associated with KS promotion, including classic KS. ![]() 2Īlthough both of our patients similarly experienced durable partial responses to PD-1 inhibition, it is of paramount importance to keep in mind that up to 15% of patients may experience severe immune-related adverse events (irAEs), most often requiring the administration of high doses of steroids and/or immunosuppressive treatments. ![]() We read with great interest the article by Saller et al, 1 which extends the observations of our previous report of 2 cases of classic Kaposi sarcoma (KS) successfully treated with PD-1 blockade. Response to Checkpoint Inhibitor Therapy in Advanced Classic Kaposi Sarcoma: A Case Report and Immunogenomic Study. ![]()
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